Former of Turn Trajectory of Sliding Valve Shaft of Gas Line

Former of turn trajectory of sliding valve shaft of gas line, that allows to provide desired motion trajectory of sliding valve and its full closing, is considered in that paper. Imitation model of that former, research results, which allow to detect influence of gain factor and time constant of position controller on value of speed error, that has impact on delay of output coordinate from setting, and that results to delay of sliding valve motion process to setting position point, are shown

Tofacitinib Loaded Squalenyl Nanoparticles for Targeted Follicular Delivery in Inflammatory Skin Diseases

Tofacitinib (TFB), a Janus kinase inhibitor, has shown excellent success off-label in treating various dermatological diseases, especially alopecia areata (AA). However, TFB’s safe and targeted delivery into hair follicles (HFs) is highly desirable due to its systemic adverse effects. Nanoparticles (NPs) can enhance targeted follicular drug delivery and minimize interfollicular permeation and thereby reduce systemic drug exposure. In this study, we report a facile method to assemble the stable and uniform 240 nm TFB loaded squalenyl derivative (SqD) nanoparticles (TFB SqD NPs) in aqueous solution, which allowed an excellent loading capacity (LC) of 20%. The SqD NPs showed an enhanced TFB delivery into HFs compared to the aqueous formulations of plain drug in an ex vivo pig ear model. Furthermore, the therapeutic efficacy of the TFB SqD NPs was studied in a mouse model of allergic dermatitis by ear swelling reduction and compared to TFB dissolved in a non-aqueous mixture of acetone and DMSO (7:1 v/v). Whereas such formulation would not be acceptable for use in the clinic, the TFB SqD NPs dispersed in water illustrated a better reduction in inflammatory effects than plain TFB’s aqueous formulation, implying both encouraging good in vivo efficacy and safety. These findings support the potential of TFB SqD NPs for developing a long-term topical therapy of AA

LEGaTO: first steps towards energy-efficient toolset for heterogeneous computing

LEGaTO is a three-year EU H2020 project which started in December 2017. The LEGaTO project will leverage task-based programming models to provide a software ecosystem for Made-in-Europe heterogeneous hardware composed of CPUs, GPUs, FPGAs and dataflow engines. The aim is to attain one order of magnitude energy savings from the edge to the converged cloud/HPC.Peer ReviewedPostprint (author's final draft

Expertise – Förderung von Lesekompetenz

Die in vielen Facetten unbefriedigenden Ergebnisse zur Lesekompetenz von Jugendlichen in Deutschland stellen den Ausgangspunkt für die vorliegende Expertise zum Thema „Förderung von Lesekompetenz“ dar, die vom Bundesministerium für Bildung und Forschung in Auftrag gegeben wurde. Das Ziel der Expertise gilt dem Nachweis, welche Möglichkeiten der Förderung von Lesekompetenz existieren, die die umfangreichen Länderaktivitäten der Förderung sinnvoll ergänzen. (DIPF/Orig.

Thematische Bereiche: die Arbeitsgemeinschaften

Die Arbeitsgemeinschaft der Einrichtungen für Weiterbildung an Hochschulen (AG-E) (Karla Kamps-Haller/Bernhard Christmann/Helmut Vogt) Zur Entstehungsgeschichte der Arbeitsgemeinschaft für das Fernstudium an Hochschulen (AG-F) (Burkhard Lehmann) Bundesarbeitsgemeinschaft Wissenschaftliche Weiterbildung für Ältere (BAG WiWA) (Thomas Bertram/Silvia Dabo-Cruz/Karin Pauls/Michael Vesper) Der Artikel beschreibt ihre Entstehungsgeschichte und die Entwicklungsschritte beim Zusammenschluss mit der DGWF und ihrer Vorläuferorganisation. Dabei liegt ein Schwerpunkt auf neuen Zielgruppenanalysen und Forschungsfragen, mit denen zukünftig belastbare empirische Daten zur Bildung Älterer erhoben werden können. Abschließend werden die künftigen Herausforderungen für die BAG WiWA skizziert. Profilbildung und Professionalisierung durch Forschung. Die Arbeitsgemeinschaft Forschung (Wolfgang Jütte/Maria Kondratjuk/Mandy Schulze) Der Beitrag fasst die Zielsetzungen, die Aktivitäten und Aufgaben der Arbeitsgruppe zusammen. Dabei wird vor allem auf das jährliche Forschungsforum als offenes Diskussionsformat mit Werkstattcharakter eingegangen

A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms

Pseudomonas aeruginosa (PA) infections can be notoriously difficult to treat and are often accompanied by the development of antimicrobial resistance (AMR). Quorum sensing inhibitors (QSI) acting on PqsR (MvfR) – a crucial transcriptional regulator serving major functions in PA virulence – can enhance antibiotic efficacy and eventually prevent the AMR. An integrated drug discovery campaign including design, medicinal chemistry-driven hit-to-lead optimization and in-depth biological profiling of a new QSI generation is reported. The QSI possess excellent activity in inhibiting pyocyanin production and PqsR reporter-gene with IC50 values as low as 200 and 11 × 10−9 m, respectively. Drug metabolism and pharmacokinetics (DMPK) as well as safety pharmacology studies especially highlight the promising translational properties of the lead QSI for pulmonary applications. Moreover, target engagement of the lead QSI is shown in a PA mucoid lung infection mouse model. Beyond that, a significant synergistic effect of a QSI-tobramycin (Tob) combination against PA biofilms using a tailor-made squalene-derived nanoparticle (NP) formulation, which enhance the minimum biofilm eradicating concentration (MBEC) of Tob more than 32-fold is demonstrated. The novel lead QSI and the accompanying NP formulation highlight the potential of adjunctive pathoblocker-mediated therapy against PA infections opening up avenues for preclinical development

LEGaTO: towards energy-efficient, secure, fault-tolerant toolset for heterogeneous computing

LEGaTO is a three-year EU H2020 project which started in December 2017. The LEGaTO project will leverage task-based programming models to provide a software ecosystem for Made-in-Europe heterogeneous hardware composed of CPUs, GPUs, FPGAs and dataflow engines. The aim is to attain one order of magnitude energy savings from the edge to the converged cloud/HPC.Peer ReviewedPostprint (author's final draft

Der Saur-Brunn in zweyerley Gestallt leiblich und geistlich : in einer zu Göppingen, den 16. Januarij 1631 zum Valete gehaltenen Predigt, einfältig beschieben

und jetzo auff sonderbares Begehren zum Truck verfertiget von M. Wolffgang Jacob Christmann, gewesten Predigern, dess h. Evangelii in Augspurg, p.t.P.K.Erscheinungsjahr gemäss dem im Titel genannten JahrTitelkupferstichBogensignaturen: A-F

Responsum Iuris Sacri. Das ist: Beständige/ auß Göttlichem Wort/ unnd anderen Satten Gründen/ gezogene Antwort/ auff folgende ... Seelen- unnd Gewissens Frage! I. Ob der jenige/ der weylund mit hoher gestaigerter Müntz bezahlet ... die völlige Erstattung thun müsse ... II. Ob einer mit gutem Gewissen begehren könne/ daß mann ihme ... gastaigertes Gelt/ widergeben solle

Durch M. Wolfgang Jacob Christman/ Evangelischer Prediger zu AugspurgVorlageform des Erscheinungsvermerks: Getruckt zu Kempten/ bey Christoff Krausen/ 1625